NEET : Multiple Choice questions: Human genome project

1. In Human genome project, the word genome refer to 

A. Complete set of Sex chromosome 

B. Complete set of haploid  chromosome

C. Complete set of diploid  chromosome

D. Complete set of autosome

Answer: B Explanation 

2. Consider the following statement and select the number of correct statements. 

1.  Human genome project has been launched to make   sequencing  of all bases of DNA.

2. Human genome project was  a 13 year project launched in 1990 and completed in 2003.

3. This project was launched  by the US Department of energy and national institute of health.

4. Japan, France , Germany and China were other partners of this project.

A. One             B. Two

C. Three.         D. Four

Answer: D Explanation 

3. Wellcome trust of which country was a major partner of this project.

A. Japan            B. UK

C. France           D. China

Answer: B Explanation 

4. The number of base pairs in human genome that have been sequenced under human genome project.

A.  3 billion        B. 6 billion

C. 3 million        D. 6 million

Answer: A Explanation 

5. Which one of the following statement does not signify that human genome project was a mega project.

A. Human genome project sequenced about 3 billion base pair that make human DNA.

B. The cost of sequencing of all base pair was 9 billion USD according to 3 USD per base pair.

C. 3300 books  with 1000 pages were required to store the data of total genome .

D. This project integrated Biology with information technology.

Answer: D Explanation

6. To store the data of genome ,  high speed computational device were used and introduced new branch of Biology called 

A. Bioprospecting

B. Biotechnology 

C. Bioinformatics 

D. Biogenetics.

Answer: C Explanation

7. Which one of the following was/ were the goal of human genome project.

A. To transfer such technology to other sector.

B.To adress ethical, legal social issue ( ELSI)

C. To store information in data base and improve tool for data analysis 

D. All of the above 

Answer: D Explanation

8. How many gene were identified under the human genome project?

A. 10000 to 15000

B. 20000 to 25000

C. 30000 to 40000

D. 1 lakh to 5 lakh

Answer: B Explanation

9. Consider the following goals of Human genome project and select the correct code:

1. To study the variations in DNA and study the genetic disorders .

2. To determine the 3 billion base pairs that make human DNA.

3.To solve the challenges in health care , agriculture , energy productions and environmental remediation.

A. 1 and 3         B. 2 and 3

C. 1 and 2         D. 1, 2 and 3

Answer: D Explanation

10. DNA sequencing has also been done for non human model such as 

A. Yeast

B. Bacteria

C. Drosophila 

D. All of the above 

Answer: D Explanation

11. For which of the following plants, DNA sequencing has been done as non human model.

A. Arabidopsis and wheat

B. Arabidopsis and rice

C. Rice and wheat

D. Arabidopsis , rice and wheat

Answer: B Explanation

12. Under non human model, DNA sequencing has been done under genome project for caenerohadbits elegans, it is a 

A. Nematode         

B. Annelids

C. Mollusca          D.Hemichordata 

Answer: A Explanation

13. What are the two methodology that had been used to sequencing under human genome project.

A. Sequence annotation and Polymerase chain reaction 

B. Express sequence tags and Polymerase chain reaction 

C. Sequence annotation and Expressed sequence tags

D. Gel electrophoresis and polymerase chain reaction

Answer: C Explanation

13. Expressed sequence Tags or EST refer to identify all gene that expressed as 

A. RNA          B. Protein 

C. Intron       D. Cistron

Answer: A Explanation

14. Sequence annotation is another blind approach in methodology of genome project that refer to identify all gene expressed as 

A. RNA and DNA 

B. Protein and Amino acids

C. Coding and non Coding sequences 

D. All of the above

Answer: C Explanation

15. What are two vector have been used to amplified the DNA fragments under human genome project.

A. Plasmid and Cosmid

B.Retrovirus and Agrobacterium 

C. Bacteriophage and plasmid

D. Bacterial and yeast artificial chromosome ( YAC & BAC)

Answer: D Explanation

16. Frederick Sanger developed the technique of automatic sequencing for 

A. DNA  and RNA

B. Amino acids and DNA 

C. RNA and protein 

D. DNA only 

Answer: B Explanation

17. What chromosome was sequenced at last in 2006 under human genome project.

A. Chromosome 1st

B . Chromosome 2nd 

C. Chromosome X

D. Chromosome Y

Answer: A Explanation

18. Which of the following statement is not correct.

A. Chromosome Ist contain 2986 gene and chromosome Y has only 231 .

B. The total gene has been found 30000 which is lower than previous estimation of 80000 to 1400000 gene. 

C. The average gene consists of 3000 bases but size of gene varies. The longest gene is dystrophin with 2.4 million bases.

D. The human genome contain 3164 billion base pairs.

Answer: D Explanation

19. Which of the following statement is/are correct for Human genome project.

A. The function of more than 50 percentage gene are unknown.

B. Less than 2 % of gene are responsible for coding the protein.

C. Repetitive sequence are repeated 100 to 1000 times.

D. All of the above.

Answer: D Explanation

20. Single nucleotide polymorphisms or Snips are  found in what number of   location where single base DNA  differences are present in human genome.

A. About 1.4 million

B. About 3.4 million

C. About 2.4 million

D. About 5.4 million

Answer: A Explanation