NEET: Multiple Choice questions: Mendelian disorders
1. Which of the following is related with the Mendelian disorder.
A. These disorders are caused by the alternation or mutation of gene on chromosome.
B. These disorders are transmitted as per the law of inheritance given by Mendel.
C. The inheritance of these disorder can be traced through the Pedigree chart.
D. Gain or loss of chromosomes is also one of the reason of these disorder.
Answer: D
2.In Colour blindness, a person is failed to distinguish between red and green colour due to defect of
A. Red cone cell of eye
B. Green cone cell of eye
C. Both red and green cone cell of eye.
D. Either red or green cone cell of eye
Answer : D Explanation
3.Which of the following statement is not correct for the Colour blindness.
A. It is a sex-linked recessive disorder.
B. This defect is due to mutation in certain genes present in the X chromosome. C. It occurs in about 0.4 per cent of males and only about 8 per cent of females. This is because the genes that lead C. The gene for red-green colour blindness are on the X chromosome.
Answer: C Explanation
4.Why do more male suffer from this disease Colour blindness.
A. Males have only one X chromosome and females have two chromosome.
B.Male lack cone cell in compare to female since beginning.
C. Female develop more cone cell during her embryonic development.
D. This mutation rarely occur in female.
Answer: A Explanation
5. A carrier woman who carries the gene of colour blindness has a what per cent chance of son of colour blind.
A. 25% B. 50 %
C. 75% D. 100%
Answers: B Explanation
6. A daughter will be normally be colour blind when
A. Her mother is a carrier and her father is colour blind.
B. Her mother is a normal and her father is colour blind.
C. Her mother is a color blind and her father is normal.
D. Her mother is a carrier and her father is also carrier.
Answer: A Explanation
7. Which of the following Mendelian disorder is / are sex linked recessive disease, and transmitted from carrier female to some of the male progeny.
A.Haemophilia and Color blindness
B. Haemophilia and Sickle cell anemia
C.Thalassemia and color blindness
D. Thalassemia and Sickle Cell anaemia
Answer: A Explanation
8.Which of the following statement is not correct for the disorder haemophilia.
A. A single protein of the cascade system involved in the clotting of blood is affected.
B. An affected individual will result in non-stop bleeding during a simple cut on body.
C. The possibility of a female becoming a haemophilic is extremely rare.
D. The transmission of Haemophilia disease is absolutely different from the color blindness.
Answer: D Explanation
9. The pedigree of Queen Victoria shows a number of descendents of which of following disease as she was a carrier of the disease.
A. Cystic fibrosis
B. Phenyl ketonuria
C. Haemophilia
D.Color blindness
Answer: C Explanation
10.Which of the following statement is correct for the sickle cell anemia.
A. This is an sex linked recessive trait.
B. It is transmitted to the offspring when both the parent are carrier for the gene.
C. An offspring is suffer from sickle cell anemia if both parent are homozygous.
D.This disorder is controlled by HBB and HBB.
Answer : B Explanation
11.Consider the following sentences and select the number of correct statement.
1.Sickle cell anemia is controlled by a single pair of allele, HbA and HbS.
2.The homozygous individuals for Hbs and Hbs is affected from sickle cell anemia.
3.The Heterozygous individuals for HbA and HbS also affected individual.
4. The Heterozygous individuals for HbA and HbS are carrier of the disease.
A. One B. Two
C. Three. D. Four
Answer : C Explanation
12. The carrier of sickle cell anemia has what per cent of probability of transmission of the mutant gene to the progeny.
A. 25% B. 50 %
C. 75% D. 100%
Answers: B Explanation 13.Sickle cell anemia. is caused by the substitution of A.Glutamic acid by Valine at the sixth position of the beta globin chain of the haemoglobin molecule.
B.Glutamic acid by Valine at the sixth position of the alpha globin chain of the haemoglobin molecule.
C.Valine by glutamic acid at the sixth position of the beta globin chain of the haemoglobin molecule.
D.Valine by glutamic acid at the sixth position of the beta globin chain of the haemoglobin molecule.
Answer: A Explanation
14.Which of the following is correct for the sickle cell anemia.
14.Which of the following is occur in the sickle cell anemia.
A. The mutant haemoglobin molecule is polymerised.
B. There is low oxygen tension C. Shape of the RBC take place from biconcave disc to sickle like structure.
D. All of the above.
Answer: D Explanation
15.Which of the following enzyme is not produced in body during the Phenyl ketonuria.
A. Succinic dehydrogenase
B.Carbonic anhydrase
C. Phenyl alanine hydroxylase
D. Atrial natriuretic factor
Answer : C Explanation
16.Enzyme phenyl alanine hydroxylase is responsible for the conversation of
A. Phenylalanine into tyrosine
B. Phenylalanine into valine
C.Tyrosine into Phenylalanine
D. Valine into phenylalanine
Answer: A Explanation
17.Which of the following statement is not correct for the Phenylketonuria.
A. Phenylalanine is not converted into tyrosine due to absence of enzyme phenyl alanine hydroxylase.
B.Phenylalanine is accumulated and converted into Phenylpyruvic acid and other derivatives.
C.Phenylketonuria does not show pleiotropy.
D. Accumulation of phenyl alanine in brain causes mental retardation and loss of skin and hair pigmentation.
Answer: C Explanation
18. Consider the following statement and select the correct code.
1. Phenyl ketonuria is inborn error of metabolism and is an autosomal recessive trait.
2. Phenylalanine and it's derivative are excreted through urine because of its poor absorption by kidney.
A. Only 1
B. Only 2
C. Both 1 and 2
D. Neither 1 nor 2
Answer: C Explanation
19. Phenylpyruvic acid and their derivatives causes Mental retardation, are formed during the
A. Cystic fibrosis
B. Phenylketonuria
C. Thalassemia
D. Sickle cell anaemia
Answer: B Explanation
20. Match the list
A. Cascade 1. Haemophilia
system
B. Point. 2. Sickle cell
Mutation Anemia
C.Phenyl 3. Phenyl keto
Pyruvic acid. nuria
D. Royal 4. Color
Disease. Blindness
A B C D
A. 1 2 3 4
B. 4 3 2 1
C. 1 2 4 3
D. 4 2 3 4
Answer: A Explanation
21. Consider the following
autosomal recessive blood disease transmitted from parents to the offspring when both the partners are unaffected carrier or heterozygous and select the correct code:
1. Haemophilia
2. Cystic fibrosis
3. Sickle cell anemia
4. Thalassemia
A. 1 and 2 B. 2 and 4
C. 3 and 4 D. 1 and 3
Answer: C Explanation
22.Which of the following statement is not correct for the Thalassemia
A. It is caused due to mutation or deletion of gene. B.This disease reduces the rate of synthesis of either alpha chain or Beta chains that make up haemoglobin.
C. Thalassemia can be classified into alpha , Beta Gamma and Delta thalassemia.
D.This disease result the formation of abnormal haemoglobin molecules resulting into anaemia.
Answer: C Explanation
23. In alpha Thalassemia, production of alpha globin chain is affected which is controlled by the gene
A. HBA and HBS
B. HBA1 and HBA2
C. HBB and HBB
D. HBA and HBB
Answer: B Explanation
24. Alpha Thalassemia is controlled by two closely linked genes HBA1 and HBA2 located on
A. Chromosome 16
B. Chromosome 11
C. Chromosome 17
D. Chromosome 18
Answer: A Explanation
25. In Beta Thalassemia, production of beta globin chain is affected which is controlled by the gene
A. HBA and HBS
B. HBA1 and HBA2
C. HBB and HBB
D. HBA and HBB
Answer: C Explanation
24. Beta Thalassemia is controlled by two closely linked genes HBB and HBB located on
A. Chromosome 16
B. Chromosome 11
C. Chromosome 17
D. Chromosome 18
Answer: B Explanation
25. Consider the following statement and select the correct code.
1. Thalassemia is a quantitative disorder due to synthesising of few haemoglobin molecules.
2. Sickle-cell anaemia is a qualitative problem of synthesising an incorrectly functioning globin.
A. Only 1
B. Only 2
C. Both 1 and 2
D. Neither 1 nor 2
Answer: C Explanation
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